These three presentations outline the key drivers of economic growth in the next economy, articulate the concept of “metro-economics” and describe the approach of Metropolitan Business Planning. The first two presentations apply these frameworks in the context of the South Bend and metropolitan Milwaukee areas, while the third presentation, delivered at the Winter meeting of the Mayor’s Innovation Project, considers the questions that regions should answer in order to understand their unique opportunities for economic growth. The South Bend presentation was delivered at the first ever South Bend Economic Summit, co-hosted by the Mayor of South Bend, and the heads of the Chamber of Commerce of St. Joseph County and the Corporate Partnership for Economic Growth. The Milwaukee presentation was delivered at a meeting of the Milwaukee 7 Regional Economic Development Advisory Council.