As major transitions in the global economy create new challenges and opportunities, new strategies for driving economic growth are emerging that are often broader in scope, larger-scale, more comprehensive and cross-sectoral. This emerging practice, in turn, calls for new institutional infrastructure and financial tools to support its effective management and implementation. This paper – informed by interviews with, and a convening of, the nation’s leading development authority practitioners and experts – begins to explore the implications of these realities for the design and practice of development authorities to support the next generation of transformative and sustainable economic development.